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- Title
3D 23Na MRI of human skeletal muscle at 7 Tesla: initial experience.
- Authors
Chang G; Wang L; Schweitzer ME; Regatte RR; Chang, Gregory; Wang, Ligong; Schweitzer, Mark E; Regatte, Ravinder R
- Abstract
<bold>Objective: </bold>To evaluate healthy skeletal muscle pre- and post-exercise via 7 T (23)Na MRI and muscle proton T(2) mapping, and to evaluate diabetic muscle pre- and post-exercise via 7 T (23)Na MRI.<bold>Methods: </bold>The calves of seven healthy subjects underwent imaging pre- and post-exercise via 7 T (23)Na MRI (3D fast low angle shot, TR/TE = 80 ms/0.160 ms, 4 mm x 4 mm x 4 mm) and 1 week later by (1)H MRI (multiple spin-echo sequence, TR/TE = 3,000 ms/15-90 ms). Four type 2 diabetics also participated in the (23)Na MRI protocol. Pre- and post-exercise sodium signal intensity (SI) and proton T(2) relaxation values were measured/calculated for soleus (S), gastrocnemius (G), and a control, tibialis anterior (TA). Two-tailed t tests were performed.<bold>Results: </bold>In S/G in healthy subjects post-exercise, sodium SI increased 8-13% (p < 0.03), then decreased (t(1/2) = 22 min), and (1)H T(2) values increased 12-17% (p < 0.03), then decreased (t(1/2 )= 12-15 min). In TA, no significant changes in sodium SI or (1)H T(2) values were seen (-2.4 to 1%, p > 0.17). In S/G in diabetics, sodium SI increased 10-11% (p < 0.04), then decreased (t(1/2) = 27-37 min) without significant change in the TA SI (-3.6%, p = 0.066).<bold>Conclusion: </bold>It is feasible to evaluate skeletal muscle via 3D (23)Na MRI at 7 T. Post-exercise muscle (1)H T(2) values return to baseline more rapidly than sodium SI. Diabetics may demonstrate delayed muscle sodium SI recovery compared with healthy subjects.
- Publication
European Radiology, 2010, Vol 20, Issue 8, p2039
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-010-1761-3