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- Title
Atypical teratoid rhabdoid tumor: long-term survival after chemoradiotherapy.
- Authors
Verma, Vivek; Johnson, Catrina; Bennion, Nathan; Bhirud, Abhijeet; Li, Sicong; McComb, Rodney; Lin, Chi
- Abstract
Purpose: Atypical teratoid rhabdoid tumors (ATRTs) arise from the central nervous system largely in the pediatric population. They portend a very poor prognosis with few long-term survivors. We describe a series of five cases at our institution. Methods: We conducted a retrospective chart review and clinical follow-up. Results: Three patients underwent chemoradiation after surgical resection; the two patients whose caretakers declined this therapy passed away soon after diagnosis. Chemoradiation included intravenous and intrathecal chemotherapy as well as intensity-modulated radiotherapy after resection. Of the patients receiving chemoradiation, two patients had infratentorial tumors, two had gross residual tumor after resection, and two were under the age of 3 years. The three patients receiving trimodality therapy remain clinically and symptomatically disease-free with follow-up times of 44, 46, and 55 months. Two of the patients have mild neuropsychiatric sequelae after therapy. Conclusions: Long-term, high-volume trials of ATRT are currently not published. We offer experience in successful long-term survival of this tumor treated with chemoradiotherapy.
- Subjects
TERATOMA; CANCER chemotherapy; CANCER radiotherapy; CENTRAL nervous system tumors; TUMOR prognosis; INFRATENTORIAL brain tumors; DISEASE complications; NEUROBEHAVIORAL disorders
- Publication
Child's Nervous System, 2015, Vol 31, Issue 8, p1393
- ISSN
0256-7040
- Publication type
Article
- DOI
10.1007/s00381-015-2723-5