We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Topical methylene blue nanoformulation for the photodynamic therapy of acne vulgaris.
- Authors
Lee, Yong-Deok; Yang, Jin-Kyoung; Han, Sunmi; Kim, Bo Ri; Shin, Jung-Won; Bang, Joona; Kim, Sehoon
- Abstract
Acne vulgaris is a common skin disease caused by multifactorial reasons involving excessive sebum secretion and inflammation by Cutibacterium acnes (C. acnes). Various conventional therapies are available for the treatment of acne vulgaris; however, topical photodynamic therapy (PDT) has attracted much attention because of its great potential for sebum-reducing, anti-inflammatory, and antimicrobial activities. Although 5-aminolevulinic acid (ALA) has been broadly used as a photosensitizer for topical PDT, it has several limitations such as long incubation time, pain, and post-inflammatory hyperpigmentation. Here, we report a biocompatible nanoformulation consisting of methylene blue and salicylic acid (MBSD), as a potent PDT and acne therapeutics, enclosed within oleic acid. Photoactivated MBSD showed antimicrobial activity against C. acnes along with long-term stability. When 24 patients with acne were treated with MBSD and light irradiation 5 times at 1-week intervals, MBSD-based PDT exhibited a remarkable reduction in acne lesions and sebum production. In addition, the therapeutic procedure was painless and safe, without any adverse events. Therefore, MBSD is a promising topical PDT agent for biocompatible, safe, and effective acne treatment.
- Subjects
ACNE; METHYLENE blue; PHOTODYNAMIC therapy; CUTIBACTERIUM acnes; SALICYLIC acid; HYPERPIGMENTATION
- Publication
Archives of Dermatological Research, 2023, Vol 315, Issue 4, p885
- ISSN
0340-3696
- Publication type
Article
- DOI
10.1007/s00403-022-02464-7