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- Title
The activation of lytic replication of Epstein-Barr virus by baculovirus-mediated gene transduction.
- Authors
Wang, L.; Shan, L.; Yin, J.; Zhao, M.; Su, D.; Zhong, J.
- Abstract
A baculoviral mammalian-cell vector was constructed to express Rta, a protein of Epstein-Barr virus (EBV) responsible for the transition from latent infection to lytic replication. EBV lytic replication and cell-growth inhibition was observed in infected D98/HR1 cells. The baculovirus caused little cytotoxicity in the non-targeted HeLa cells, compared to an adenovirus vector. It is concluded that recombinant baculovirus might have the potential as a vector for the therapy of EBV-related cancer.
- Subjects
PROTEINS; EPSTEIN-Barr virus; CELLS; BACULOVIRUSES; CANCER research
- Publication
Archives of Virology, 2006, Vol 151, Issue 10, p2047
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-006-0772-5