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- Title
Antibacterial Properties of 2-Acetylpyridine-1-Oxide Thiosemicarbazones.
- Authors
Dobek, Arthur S.; Klayman, Daniel L.; Scovill, John P.; Dickson, Jr., Edward T.
- Abstract
We have investigated the in vitro antibacterial activity of 13 2-acetylpyridine-1-oxide thiosemicarbazones and 5 thiosemicarbazides against 80 clinically significant bacterial cultures, including 13 isolates with known antibiotic resistance. Of the thiosemicarbazones tested, 5 had minimal inhibitory concentrations (MICs) of 0.25 μg/ml for Neisseria gonorrhoeae isolates; 1 of these had an MIC range of 0.25-0.5 μg/ml for the Neisseria meningitidis cultures, and 2 had MICs of 2 and 2-4 μg/ml for Staphylococcus aureus and Streptococcus faecalis isolates, respectively. Two of the thiosemicarbazides had MICs of 0.25 μg/ml for N. gonorrhoeae, whereas 2 others had MICs of 2-4 and 4-8 μg/ml for S. aureus and S. faecalis isolates, respectively. The test compounds were ineffective against the gram-negative enteric cultures and the Pseudomonas isolates. Copyright © 1986 S. Karger AG, Basel
- Publication
Chemotherapy (0009-3157), 1986, Vol 32, Issue 1, p25
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000238385