We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Diffusion of cefpirome into the cerebrospinal fluid of patients with purulent meningitis.
- Authors
Wolff, M.; Chavanet, P.; Kazmierczak, A.; Pechinot, A.; Dematons, C.; Portier, H.; Lenfant, B.
- Abstract
We evaluated the diffusion of cefpirome into the cerebrospinal fluid (CSF) of 25 patients with bacterial meningitis or ventriculitis who were receiving conventional antibiotic treatment A single cefpirome dose of 2 g was infused at day 2–3 after the onset of therapy. Concentrations of cefpirome in serum and CSF obtained at 2, 4, 8 or 12 h after the infusion were determined by high-performance liquid chromatography. The mean (±S.E.M.) concentrations of cefpirome in CSF ranged from 2·26± 1·16 to 4·17±0·83 mg/l. These concentrations were higher than the MBCs for the pathogens usually responsible for bacterial meningitis.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1992, Vol 29, Issue suppl_A, p59
- ISSN
0305-7453
- Publication type
Article