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- Title
Pharmacokinetic study of ceftazidime in bone and serum of patients undergoing hip and knee arthroplasty.
- Authors
Leigh, D. A.; Griggs, Janice; Tighe, Christine M.; Powell, H. D. W.; Church, J. C. T.; Wise, K.; Channon, G.; Curtis, Linda B.; Griggs, J; Tighe, C M; Powell, H D; Church, J C; Curtis, L B
- Abstract
Twenty-eight patients undergoing hip arthroplasty and 15 undergoing knee arthroplasty, received chemoprophylaxis with ceftazidime 1·0 g administered intravenously at the time of induction of anaesthesia, followed by two doses of 500 mg given intramuscularly 6 and 12 h later. The mean bone concentration in hip arthroplasty showed a general rise towards a maximum of approximately 20 mg/kg when the exposure time (interval between antibiotic injection and removal of bone sample) was 35–40 min, with values ranging from 4·4 to 21·2 mg/kg (mean 14·4 mg/kg). The patients undergoing knee arthroplasty present a complicated pharmacokinetic problem, as the use of a tourniquet limits the exposure time. Bone concentrations of ceftazidime were highest at sampling times greater than 20 min in these patients (mean level of 15·9 mg/kg for femoral bone and 13·1 mg/kg for tibial bone).
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1985, Vol 16, Issue 5, p637
- ISSN
0305-7453
- Publication type
journal article