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- Title
Inhaled anesthetic agent sedation in the ICU and trace gas concentrations: a review.
- Authors
Herzog-Niescery, Jennifer; Seipp, Hans-Martin; Weber, Thomas Peter; Bellgardt, Martin
- Abstract
There is a growing interest in the use of volatile anesthetics for inhalational sedation of adult critically ill patients in the ICU. Its safety and efficacy has been demonstrated in various studies and technical equipment such as the anaesthetic conserving device (AnaConDa™; Sedana Medical, Uppsala, Sweden) or the MIRUS™ system (Pall Medical, Dreieich, Germany) have significantly simplified the application of volatile anesthetics in the ICU. However, the personnel's exposure to waste anesthetic gas during daily work is possibly disadvantageous, because there is still uncertainty about potential health risks. The fact that average threshold limit concentrations for isoflurane, sevoflurane and desflurane either differ significantly between countries or are not even defined at all, leads to raising concerns among ICU staff. In this review, benefits, risks, and technical aspects of inhalational sedation in the ICU are discussed. Further, the potential health effects of occupational long-term low-concentration agent exposure, the staffs' exposure levels in clinical practice, and strategies to minimize the individual gas exposure are reviewed.
- Subjects
INHALATION anesthetics; ANESTHETIC synthesis; MIRUS Therapeutics Corp.; ISOFLURANE; SEVOFLURANE; INTENSIVE care patients; THERAPEUTICS; ENVIRONMENTAL exposure prevention; AIR pollution; ANESTHESIA; CATASTROPHIC illness; INHALATION anesthesia; INTENSIVE care units; RISK assessment; MECHANICAL ventilators; OCCUPATIONAL hazards; PRODUCT design; ENVIRONMENTAL exposure
- Publication
Journal of Clinical Monitoring & Computing, 2018, Vol 32, Issue 4, p667
- ISSN
1387-1307
- Publication type
journal article
- DOI
10.1007/s10877-017-0055-6