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- Title
Editorial for "Gadolinium Retention and Nephrotoxicity in a Mouse Model of Acute Ischemic Stroke: Linear Versus Macrocyclic Agents".
- Authors
Jeong, Keun‐Yeong
- Abstract
This article discusses the potential risk of renal toxicity in patients with acute ischemic stroke (AIS) who undergo contrast-enhanced MR angiography (CE-MRA) using gadolinium-based contrast agents (GBCA). While GBCA has been considered safe with low side effects, evidence suggests a correlation between GBCA injection and renal toxicity. A study on an AIS animal model found that renal toxicity was induced by gadopentetate, one of the types of GBCA used, leading to increased serum creatinine levels and renal injury. The article emphasizes the importance of considering renal function before using GBCA in AIS patients to reduce the risk of renal toxicity.
- Subjects
ISCHEMIC stroke; NEPHROTOXICOLOGY; LABORATORY mice; HEMORRHAGIC stroke; GADOLINIUM
- Publication
Journal of Magnetic Resonance Imaging, 2024, Vol 59, Issue 5, p1862
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.28932