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- Title
Component migration, bone mineral density changes, and bone turnover markers in cementless and cemented total knee arthroplasty: a prospective randomized RSA study in 53 patients with 2-year follow-up.
- Authors
Linde, Karina Nørgaard; Rytter, Søren; Søballe, Kjeld; Madsen, Frank; Langdahl, Bente; Stilling, Maiken
- Abstract
Purpose: Cementless tibial components migrate initially until osseointegration and preserve periprosthetic bone. Cemented tibial components are fixed from surgery but loose periprosthetic bone. Little is known about bone formation and resorption biomarkers in relation to component fixation and bone mineral density (BMD) changes of cementless and cemented total knee arthroplasty. We hypothesize a similar migration of cemented and cementless tibial components between 1- and 2-year follow-up indicating a stable long-term fixation. Methods: In a prospective patient-blinded randomized study, we compared cementless (n = 27) and cemented (n = 26) tibial components with radiostereometry measured migration (MTPM = Maximum Total Point Motion: point of component that migrates the most) and changes in BMD and biochemical bone turnover markers (BTMs) until 24 months after surgery. Results: The mean MTPM between 12 and 24 months were similar between groups with − 0.06 mm (95% CI − 0.23; 0.11) in the cementless group compared to 0.02 mm (95% CI − 0.07; 0.11) in the cemented group. However, there was a higher proportion of cementless components (16/25) than cemented components (7/24) with continuous migration (MTPM > 0.2 mm) (p = 0.02). In the medial and anterior region below the tibial components, the BMD increased by mean 1.8% and 7.4% for cementless components and decreased by mean 8.6% and 4.2% for cemented components until 24-month follow-up. In both groups, BTMs initially showed increased bone resorption (CTx) and bone formation (P1NP) followed by normalization to pre-operative levels at 6 months post-surgery. Conclusion: More cementless components than cemented components showed continues migration which suggest a higher risk of early revision. Bone turnover increased post-surgery in both groups, but did not explain the difference in change in periprosthetic BMD. Level of evidence: I.
- Publication
Knee Surgery, Sports Traumatology, Arthroscopy, 2022, Vol 30, Issue 9, p3100
- ISSN
0942-2056
- Publication type
Article
- DOI
10.1007/s00167-022-06860-4