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- Title
3D-printed GelMA/CaSiO<sub>3</sub> composite hydrogel scaffold for vascularized adipose tissue restoration.
- Authors
Zhang, Jupei; Zeng, Zhen; Chen, Yanxin; Deng, Li; Zhang, Yanxin; Que, Yumei; Jiao, Yiren; Chang, Jiang; Dong, Zhihong; Yang, Chen
- Abstract
The increased number of mastectomies, combined with rising patient expectations for cosmetic and psychosocial outcomes, has necessitated the use of adipose tissue restoration techniques. However, the therapeutic effect of current clinical strategies is not satisfying due to the high demand of personalized customization and the timely vascularization in the process of adipose regeneration. Here, a composite hydrogel scaffold was prepared by three-dimensional (3D) printing technology, applying gelatin methacrylate anhydride (GelMA) as printing ink and calcium silicate (CS) bioceramic as an active ingredient for breast adipose tissue regeneration. The in vitro experiments showed that the composite hydrogel scaffolds could not only be customized with controllable architectures, but also significantly stimulated both 3T3-L1 preadipocytes and human umbilical vein endothelial cells in multiple cell behaviors, including cell adhesion, proliferation, migration and differentiation. Moreover, the composite scaffold promoted vascularized adipose tissue restoration under the skin of nude mice in vivo. These findings suggest that 3D-printed GelMA/CS composite scaffolds might be a good candidate for adipose tissue engineering.
- Subjects
KASHIO Keisanki KK; HYDROGELS; UMBILICAL veins; CALCIUM silicates; CELL adhesion; ADIPOSE tissues; ENDOTHELIAL cells; TISSUE engineering
- Publication
Regenerative Biomaterials, 2023, Vol 10, p1
- ISSN
2056-3418
- Publication type
Article
- DOI
10.1093/rb/rbad049