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- Title
Extreme skewing of X chromosome inactivation in mothers of homosexual men.
- Authors
Bocklandt, Sven; Horvath, Steve; Vilain, Eric; Hamer, Dean H.
- Abstract
Human sexual preference is a sexually dimorphic trait with a substantial genetic component. Linkage of male sexual orientation to markers on the X chromosome has been reported in some families. Here, we measured X chromosome inactivation ratios in 97 mothers of homosexual men and 103 age-matched control women without gay sons. The number of women with extreme skewing of X-inactivation was significantly higher in mothers of gay men (13/97=13%) compared to controls (4/103=4%) and increased in mothers with two or more gay sons (10/44=23%). Our findings support a role for the X chromosome in regulating sexual orientation in a subgroup of gay men.
- Subjects
X chromosome; SEX chromosomes; GAY men; SEXUAL orientation; LINKAGE (Genetics); GENES; GENETIC research
- Publication
Human Genetics, 2006, Vol 118, Issue 6, p691
- ISSN
0340-6717
- Publication type
Article
- DOI
10.1007/s00439-005-0119-4