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- Title
Circulating Estrogen Levels and Self-Reported Health and Mobility Limitation in Community-Dwelling Men of the Framingham Heart Study.
- Authors
Jasuja, Guneet Kaur; Travison, Thomas G.; Murabito, Joanne M.; Davda, Maithili N.; Rose, Adam J.; Basaria, Shehzad; Coviello, Andrea; Vasan, Ramachandran S.; D'Agostino, Ralph; Bhasin, Shalender
- Abstract
<bold>Background: </bold>Self-rated health is a commonly used global indicator of health status. Few studies have examined the association of self-rated health and mobility with estrone and estradiol in men. Accordingly, we determined the cross-sectional, incident, and mediating relations between circulating estrone and estradiol levels with self-rated health, mobility limitation, and physical performance in community-dwelling men.<bold>Methods: </bold>The cross-sectional sample included 1,148 men, who attended Framingham Offspring Study Examinations 7 and 8. Estrone and estradiol levels were measured using liquid chromatography tandem mass spectrometry at Examination 7. Self-reported mobility limitation and self-rated health were assessed at Examinations 7 and 8. Additionally, short physical performance battery, usual walking speed, and grip strength were assessed at Examination 7.<bold>Results: </bold>In incident analysis, estradiol levels at Examination 7 were associated with increased odds of fair or poor self-rated health at Examination 8, after adjusting for age, body mass index, comorbidities, and testosterone levels; in an individual with 50% greater estradiol than other, the odds of reporting "fair or poor" self-rated health increased by 1.78 (95% confidence interval: 1.25-2.55; p = .001). Neither estrone nor estradiol levels were associated with any physical performance measure at baseline.<bold>Conclusions: </bold>Higher circulating levels of estradiol are associated with increased risk of incident fair/poor self-rated health in community-dwelling men. The mechanisms by which circulating levels of estradiol are related to self-rated health in men need further investigation.
- Subjects
UNITED States; ESTROGEN; MEN'S health; ESTRONE; ESTRADIOL; PHYSICAL activity; LIQUID chromatography-mass spectrometry; WALKING speed; GRIP strength; GERIATRIC assessment; AGING; SELF-evaluation; STATISTICS; STEROIDS; SYMPTOMS; HEALTH equity; INDEPENDENT living; CROSS-sectional method
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2017, Vol 72, Issue 8, p1137
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glw197