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- Title
Rapamycin Increases Mortality in db/db Mice, a Mouse Model of Type 2 Diabetes.
- Authors
Sataranatarajan, Kavithalakshmi; Ikeno, Yuji; Bokov, Alex; Feliers, Denis; Yalamanchili, Himabindu; Hak Joo Lee; Mariappan, Meenalakshmi M.; Tabatabai-Mir, Hooman; Diaz, Vivian; Prasad, Sanjay; Javors, Martin A.; Choudhury, Goutam Ghosh; Hubbard, Gene B.; Barnes, Jeffrey L.; Richardson, Arlan; Kasinath, Balakuntalam S.; Lee, Hak Joo; Ghosh Choudhury, Goutam
- Abstract
We examined the effect of rapamycin on the life span of a mouse model of type 2 diabetes, db/db mice. At 4 months of age, male and female C57BLKSJ-lepr (db/db) mice (db/db) were placed on either a control diet, lacking rapamycin or a diet containing rapamycin and maintained on these diets over their life span. Rapamycin was found to reduce the life span of the db/db mice. The median survival of male db/db mice fed the control and rapamycin diets was 349 and 302 days, respectively, and the median survival of female db/db mice fed the control and rapamycin diets was 487 and 411 days, respectively. Adjusting for gender differences, rapamycin increased the mortality risk 1.7-fold in both male and female db/db mice. End-of-life pathological data showed that suppurative inflammation was the main cause of death in the db/db mice, which is enhanced slightly by rapamycin treatment.
- Subjects
RAPAMYCIN; TYPE 2 diabetes treatment; INFLAMMATION treatment; GENDER differences (Psychology); MORTALITY; ANIMAL experimentation; CAUSES of death; DIABETES; IMMUNOSUPPRESSIVE agents; INFLAMMATION; LONGEVITY; MICE; TYPE 2 diabetes; RESEARCH funding; SEX distribution; TREATMENT effectiveness; PHARMACODYNAMICS
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2016, Vol 71, Issue 7, p850
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glv170