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- Title
Tumorigenesis: The collagen connection.
- Authors
Dell, Helen
- Abstract
The article presents a study related to collagens. The FNC1 sequence contains a binding site for laminin-5, an extracellular protein that is found in SCC. Laminin-5 interacts physically with collagen VII, but the FNC1 antibodies disrupt this partnership. Moreover, it seems that laminin-5 is necessary for FNC1 to promote tumour invasion, as antibodies to laminin-5 inhibited this process. Whether the presence of the FNC1 region in RDEB individuals is a reliable predictor that they will develop SCC has yet to be proven. But the authors suggest that as collagen VII and laminin-5 are extracellular, they will in principle be accessible to therapeutics such as antibodies.
- Subjects
COLLAGEN; IMMUNOGLOBULINS; EXTRACELLULAR matrix proteins; THERAPEUTICS; PROTEINS; BLOOD proteins
- Publication
Nature Reviews Cancer, 2005, Vol 5, Issue 5, p336
- ISSN
1474-175X
- Publication type
Article
- DOI
10.1038/nrc1615