We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Plasma neurofilament light chain concentrations are elevated in youth‐onset type 2 diabetes and associated with neuropathy.
- Authors
Fridman, Vera; Sillau, Stefan; Ritchie, Alanna; Bockhorst, Jacob; Coughlan, Christina; Araya, Paula; Espinosa, Joaquin M.; Smith, Keith; Lange, Ethan M.; Lange, Leslie A.; Ghormli, Laure El; Drews, Kimberly L.; Zeitler, Philip; Reusch, Jane E. B.
- Abstract
Background and Aims: The lack of easily measurable biomarkers remains a challenge in executing clinical trials for diabetic neuropathy (DN). Plasma Neurofilament light chain (NFL) concentration is a promising biomarker in immune‐mediated neuropathies. Longitudinal studies evaluating NFL in DN have not been performed. Methods: A nested case–control study was performed on participants with youth‐onset type 2 diabetes enrolled in the prospective Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study. Plasma NFL concentrations were measured at 4‐year intervals from 2008 to 2020 in 50 participants who developed DN and 50 participants with type 2 diabetes who did not develop DN. Results: NFL concentrations were similar in the DN and no DN groups at the first assessment. Concentrations were higher in DN participants at all subsequent assessment periods (all p <.01). NFL concentrations increased over time in both groups, with higher degrees of change in DN participants (interaction p =.045). A doubling of the NFL value at Assessment 2 in those without DN increased the odds of ultimate DN outcome by an estimated ratio of 2.86 (95% CI: [1.30, 6.33], p =.0046). At the final study visit, positive Spearman correlations (controlled for age, sex, diabetes duration, and BMI) were observed between NFL and HbA1c (0.48, p <.0001), total cholesterol (0.25, p =.018), and low‐density lipoprotein (LDL (0.30, p =.0037)). Negative correlations were observed with measures of heart rate variability (−0.42 to −0.46, p = <.0001). Interpretation: The findings that NFL concentrations are elevated in individuals with youth‐onset type 2 diabetes, and increase more rapidly in those who develop DN, suggest that NFL could be a valuable biomarker for DN.
- Subjects
BIOMARKERS; STATISTICS; GLYCOSYLATED hemoglobin; NERVE tissue proteins; CONFIDENCE intervals; DIABETIC neuropathies; AGE distribution; CASE-control method; RETROSPECTIVE studies; LOW density lipoproteins; TYPE 2 diabetes; RISK assessment; SEX distribution; DESCRIPTIVE statistics; DISEASE duration; HEART beat; RESEARCH funding; ODDS ratio; DATA analysis; BODY mass index; CHOLESTEROL; DISEASE risk factors
- Publication
Journal of the Peripheral Nervous System, 2023, Vol 28, Issue 3, p460
- ISSN
1085-9489
- Publication type
Article
- DOI
10.1111/jns.12575