We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Type I interferons promote cross-priming: more functions for old cytokines.
- Authors
Beignon, Anne-Sophie; Skoberne, Mojca; Bhardwaj, Nina
- Abstract
The priming of CD8+ T cells requires T cell receptor-mediated recognition of peptide-major histocompatibility complex (MHC) class I complexes on antigen-presenting cells (APCs). These peptides are generally derived from proteins synthesized endogenously within the cytoplasm of APCs, as during viral infection. Cytoplasmic proteosomes and peptidases degrade these proteins into peptides, after which they are translocated into the endoplasmic reticulum for access to newly synthesized MHC class I molecules and transport to the cell surface. Direct evidence that type I IFNs are important in cross-presentation initially came from studies showing that IFN-&alpha/β deficient mice are less efficient at cross-priming CD8+ T cells to combinations of antigen and oligodeoxynucleotides containing immunostimulatory CpG motifs. Using a more direct approach, researchers show enhanced cross-priming of CD8+ T cells to soluble or cell-associated ovalbumin when either high IFN-α/β-inducing virus (lymphocytic choriomeningitis virus) or IFN-α protein is co-administered. The cross-primed CD8+ T cells produce IFN-α, acquire antigenspecific cytolytic activity and are strongly protective against a challenge with ovalbumin-expressing vaccinia virus.
- Subjects
T cell receptors; MAJOR histocompatibility complex; PEPTIDES; CD antigens; VIRUS diseases; INTERFERONS
- Publication
Nature Immunology, 2003, Vol 4, Issue 10, p939
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni1003-939