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- Title
Changes of Coagulation and Fibrinolytic Status Detected by Thromboelastography (TEG6s ®) in Pregnancy, Labor, Early Postpartum, Postpartum Hemorrhage and Heparin Treatment for Perinatal Venous Thrombosis.
- Authors
Suemitsu, Chiharu; Fudaba, Megumi; Kitada, Kohei; Kurihara, Yasushi; Tahara, Mie; Hamuro, Akihiro; Misugi, Takuya; Nakano, Akemi; Koyama, Masayasu; Tachibana, Daisuke
- Abstract
The aims of this study are to evaluate coagulation and fibrinolytic features using TEG6s® in normal pregnant courses, in the early postpartum period and in cases with postpartum hemorrhage (PPH) caused by uterine atony. We also analyze cases with deep venous thrombosis (DVT) and/or pulmonary embolism (PE) under treatment with unfractionated heparin. The non-pregnant women (n = 13) and healthy pregnant women (at 9–13 weeks of gestation (n = 13), at 27–30 weeks of gestation (n = 14), at 35–38 weeks of gestation (n = 14)) were cross-sectionally studied, while the normal pregnant women at delivery (n = 14) were sequentially investigated. Blood samples from those patients with PPH (n = 15) and DVT and/or PE (n = 11) were also obtained and compared with those of normal women. Significant changes of clot formation parameters were observed in all parameters and, interestingly, fibrinolytic parameter (LY30) was maintained at a low value even within 120 min after placental delivery (median of LY30; 0) and also in cases with uterine atony (median of LY30; 0.1). The parameter that indicates the effectiveness of heparin showed strong correlation (R = 0.788) with activated partial thromboplastin time. Thromboelastography may be less sensitive to fibrinolysis in the conditions of uterine atonic bleeding.
- Subjects
FIBRINOLYTIC agents; POSTPARTUM hemorrhage; CROSS-sectional method; THROMBELASTOGRAPHY; PROTHROMBIN; GESTATIONAL age; BLOOD collection; VENOUS thrombosis; COMPARATIVE studies; DESCRIPTIVE statistics; LABOR (Obstetrics); HEPARIN; PERINATAL period
- Publication
Healthcare (2227-9032), 2022, Vol 10, Issue 10, pN.PAG
- ISSN
2227-9032
- Publication type
Article
- DOI
10.3390/healthcare10102060