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- Title
血清 cTnI、CK-MB 及 IGF-1 在新生儿高胆红素血症中的变化 及临床意义.
- Authors
王旭荣; 刘柳叶; 张北宁; 韩丽丽; 王 军
- Abstract
Objective: The changes and clinical value of serum cTnI, CK-MB and IGF-1 in neonatal hyperbilirubinemia were analyzed. Methods: Eighty neonatal hyperbilirubinemia full-term neonates (observation group) and 80 non-bilirubin full-term neonates (control group) who were treated in the neonatal department to our hospital from January 2015 to December 2019 were selected as studies. Collected hospitalization data, including gestational age, age, birth weight, total serum bilirubin value, CK-MB, cTnT, and IGF-1, skull magnetic resonance, clinical manifestations, and follow-up data after discharge for all children. According to the level of bilirubin, the observation components were divided into mild group (33 cases), moderate group (27 cases), and severe group (20 cases), and their levels were compared: TBIL, IGF-1, CK-MB, cTnT levels. Results: The differences of TBIL, CK-MB and cTnT levels of neonates in each group were statistically significant (P<0.05). The TBIL, CK-MB and cTnT values in the severe jaundice group were higher than those in the mild, moderate jaundice group and the control group, while IGF-1 was lower than that in the mild, moderate jaundice group and the control group (P<0.05). The moderate jaundice group TBIL, CK-MB, cTnT were higher than mild jaundice group and control group, IGF-1 was lower than mild jaundice group and control group (P<0.05). TBIL, CK-MB, cTnT in mild jaundice group were higher than control group, IGF-1 was lower than the control group (P<0.05). Serum cTnT was positively correlated with TBIL levels (r=0.587, P<0.05). Serum CK-MB was not significantly correlated with TBIL levels (r=0.220, P>0.05); serum IGF-1 was negatively correlated with TBIL levels (r=-0.568, P<0.05). The serum IGF-1 value of children with abnormal globus pallidus signal group was (11.05±0.51) ng/mL, which was significantly lower than that of normal globus pallidus signal group (14.22±2.67) ng/mL (P<0.05). The serum TBIL level of children was (347.62±33.01) µmol/L and pallor normal signal group (341.75±35.14) µmol/L was not significantly different (P>0.05). Conclusion: Detection of serum cTnT and IGF-1 levels could help predict the occurrence of neonatal hyperbilirubinemia myocardial injury and encephalopathy.
- Subjects
EXCEPTIONAL children; NEONATAL jaundice; GLOBUS pallidus; BIRTH weight; CONTROL groups
- Publication
Progress in Modern Biomedicine, 2020, Vol 20, Issue 21, p4101
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2020.21.022