We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
不同剂量阿伐他汀联合阿司匹林治疗原发性高血压 并动脉粥样硬化的临床研究
- Authors
孙磊; 孟锦; 赵宏伟; 刘莹; 于晓红
- Abstract
Objective: To explore the clinical efficacy of different doses of atorvastatin combined with aspirin in the treatment of primary hypertension with atherosclerosis. Methods: The clinical data of patients with essential hypertension treated by atorvastatin and aspirin in our hospital from January 2015 to December were randomly divided into the control group and the experimental group, 40 cases in each group. The experimental group was given oral high dose of atorvastatin(40 mg/d) combined with aspirin enteric-coated tablet(100 mg/d), while the control group was given low dose of atorvastatin(20 mg/d) combined with aspirin enteric-coated tablet(100 mg/d), the course of treatment was 3 months. The levels of total cholesterol(TC), high-density lipoproteincholesterol(HDL-C),triglyceride(TG), low-density lipoprotein cholesterol(LDL-C), systolic blood pressure(SBP), diastolic blood pressure(DBP) and carotid plaque grade were observed and compared before and after the treatment between two groups. Results: After treatment, the levels of SBP,DBP, serum TC, TG and LDL-C in the two groups were significantly lower than those before treatment, the serum HDL-C levels were significantly higher than before treatment(P0.05). The levels of SBP, DBP, serum TC, TG and LDL-C in the experimental group were significantly lower than those in the control group(P0.05), serum HDL-C level was significantly higher than that in the control group(P0.05). The proportion of carotid plaque 0-I in the experimental group was significantly higher than that of the control group(P0.05).Conclusions: High dose of atorvastatin(40 mg/d) combined with aspirin enteric-coated tablets(100 mg/d) is more effective than low dose atorvastatin(20 mg/d) combined with aspirin enteric-coated tablets(100 mg/d) in the treatment of primary hypertension with atherosclerosis, it can reduce the blood pressure, regulate the blood lipids and improve the prognosis of patients.
- Publication
Progress in Modern Biomedicine, 2018, Vol 18, Issue 4, p681
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2018.04.017