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- Title
Nucleobindin-2 在乳腺癌中表达的临床病理意义.
- Authors
孙小年; 胡丹妮; 卢雪琳; 王江涛; 李晶
- Abstract
Objective: To investigate the expression and clinical significance of NUCB2 in breast cancer, and provide evidence for its functional research. Methods: Cases of breast cancer and the corresponding clinical data including follow-up data were collected, immunohistochemical method was used to detect the benign lesions, with/without lymph node metastasis of breast cancer and matched lymph node metastasis foci of nucb2 expression. The relationship between nucb2 expression in breast cancer and clinicopathological parameters, survival state were analyzed. Results: Immunohistochemical results showed that the positive expression rates of NUCB2 in BBD, MBC, NMBC and PMLN were 90% (45/50), 82.1% (87/106), 48.2% (40/83), 47.2% (50/106) respectively. The positive expression rate of NUCB2 in BBD was significantly higher than that of PMLN and NMBC, but there was no significant difference in MBC. The positive expression rate of MBC in was significantly higher than that in NMBC; the positive expression rate NUCB2 in MBC was significantly higher than that in PMLN. Clinical pathological analysis showed that the expression of NUCB2 was significantly associated with lymph node metastasis (p=0.000), clinical stage (p=0.001) and estrogen positive expression (p=0.020) in primary breast cancer. But there was no significant correlation with age, tumor size, histological grade, histological type, progesterone receptor, HER2 expression, and menopause. Kaplan-Meier analysis, the results showed that the overall survival rate of NUCB2 positive expression cases was lower than that of the negative cases (p=0.004). Conclusions: NUCB2 expression in breast cancer was closely related to the lymph node metastasis, clinical stage,. estrogen positive expression, survival status, which might be important significance in malignant progression and prognosis.
- Publication
Progress in Modern Biomedicine, 2017, Vol 17, Issue 6, p1094
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2017.06.024