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- Title
Brain structure and neurological and behavioural functioning in infants born preterm.
- Authors
Kelly, Claire E; Thompson, Deanne K; Cheong, Jeanie LY; Chen, Jian; Olsen, Joy E; Eeles, Abbey L; Walsh, Jennifer M; Seal, Marc L; Anderson, Peter J; Doyle, Lex W; Spittle, Alicia J
- Abstract
<bold>Aim: </bold>To examine: (1) relationships between brain structure, and concurrently assessed neurological and behavioural functioning, in infants born preterm at term-equivalent age (TEA; approximately 38-44wks); and (2) whether brain structure-function relationships differ between infants born very (24-29wks) and moderate-late (32-36wks) preterm.<bold>Method: </bold>A total of 257 infants (91 very preterm, 166 moderate-late preterm; 120 males, 137 females) had structural magnetic resonance imaging (MRI) and neurological and behavioural assessments (Prechtl's general movements assessment, Neonatal Intensive Care Unit Network Neurobehavioral Scale [NNNS] and Hammersmith Neonatal Neurological Examination [HNNE]). Two hundred and sixty-three infants (90 very preterm, 173 moderate-late preterm; 131 males, 132 females) had diffusion MRI and assessments. Associations were investigated between assessment scores and global brain volumes using linear regressions, regional brain volumes using Voxel-Based Morphometry, and white matter microstructure using Tract-Based Spatial Statistics.<bold>Results: </bold>Suboptimal scores on some assessments were associated with lower fractional anisotropy and/or higher axial, radial, and mean diffusivities in some tracts: NNNS attention and reflexes, and HNNE total score and tone, were associated with the corpus callosum and optic radiation; NNNS quality of movement with the corona radiata; HNNE abnormal signs with several major tracts. Brain structure-function associations generally did not differ between the very and moderate-late preterm groups.<bold>Interpretation: </bold>White matter microstructural alterations may be associated with suboptimal neurological and behavioural performance in some domains at TEA in infants born preterm. Brain structure-function relationships are similar for infants born very preterm and moderate-late preterm.<bold>What This Paper Adds: </bold>Brain volume is not related to neurological/behavioural function in infants born preterm at term. White matter microstructure is related to some neurological/behavioural domains at term. Brain-behaviour relationships are generally similar for infants born very preterm and moderate-late preterm.
- Subjects
PREMATURE infants; NEUROLOGIC examination; CORPUS callosum; DIFFUSION magnetic resonance imaging; VOXEL-based morphometry; ANTHROPOMETRY; BRAIN; COMPARATIVE studies; INFANT psychology; LONGITUDINAL method; MAGNETIC resonance imaging; RESEARCH methodology; MEDICAL cooperation; REFLEXES; RESEARCH; RESEARCH funding; PSYCHOSOCIAL factors; EVALUATION research; BODY movement
- Publication
Developmental Medicine & Child Neurology, 2019, Vol 61, Issue 7, p820
- ISSN
0012-1622
- Publication type
journal article
- DOI
10.1111/dmcn.14084