We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
RS11212617 is associated with metformin treatment response in type 2 diabetes in Shanghai local Chinese population.
- Authors
Zhou, Y.; Guo, Y.; Ye, W.; Wang, Y.; Li, X.; Tian, Y.; Liu, Z.; Li, S.; Yan, J.
- Abstract
Objective This study was designed to examine the relevance of single-nucleotide polymorphism ( SNP) rs11212617 with treatment success in type 2 diabetes patients from Shanghai local Chinese Han population. Methods We genotyped rs11212617 in incident metformin users of type 2 diabetes patients from Shanghai local Chinese Han population. Association between rs11212617 and changes in HbA1c, fasting plasma glucose and postprandial glucose level were analysed. Results Two hundred and seventy-four incident metformin users were included in the study sample. The SNP rs11212617 was significantly associated with metformin response in Shanghai local Chinese Han population. Conclusion The rs11212617 is associated with a reduction in HbA1c, fasting plasma glucose and postprandial glucose level. These results suggest that metformin treatment may be more efficacious in Shanghai and valuable for Chinese daily clinical practice.
- Publication
International Journal of Clinical Practice, 2014, Vol 68, Issue 12, p1462
- ISSN
1368-5031
- Publication type
Article
- DOI
10.1111/ijcp.12534