We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Design, Synthesis, and Anticancer Activity of Bis-isoxazole Incorporated Benzothiazole Derivatives.
- Authors
Cherukumalli, Purna Koteswara Rao; Tadiboina, Bhaskara Rao; Gulipalli, Kali Charan; Bodige, Srinu; Gangarapu, Kiran; Sridhar, Gattu
- Abstract
A novel series of bis-isoxazole incorporated benzothiazole derivatives has been designed and synthesized. Molecular structures of the compounds have been confirmed by 1H and 13C NMR, and mass spectra. All products have been tested for their in vitro anticancer activity against breast MCF-7 and MDA MB-231, lungs A549, and prostate DU-145 cancer cell lines using the MTT assay and etoposide as a standard drug. Most of the compounds have demonstrated good to moderate activity, and some of those have exhibited more potent activity than etoposide.
- Subjects
ISOXAZOLES; BENZOTHIAZOLE derivatives; MASS spectrometry; MOLECULAR structure; MOLECULES; PROSTATE cancer
- Publication
Russian Journal of General Chemistry, 2020, Vol 90, Issue 10, p1981
- ISSN
1070-3632
- Publication type
Article
- DOI
10.1134/S1070363220100229