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- Title
Tenascin-C Levels in the Vitreous of Patients with Proliferative Vitreoretinopathy.
- Authors
Y. Mitamura; S. Takeuchi; K. Ohtsuka; A. Matsuda; T. Yamamoto; S. Yamamoto; N. Hiraiwa; M. Kusakabe
- Abstract
Purpose: To determine whether tenascin-C levels are elevated in the vitreous of patients with proliferative vitreoretinopathy (PVR). Methods: We assayed tenascin-C levels in vitreous samples of 110 consecutive patients with PVR (30 eyes), rhegmatogenous retinal detachment (RRD; 32 eyes), and macular hole or idiopathic epiretinal membrane (controls, 48 eyes) using an enzyme-linked immunosorbent assay. Results: Vitreous levels of tenascin-C (median [range]) were significantly greater in PVR (845.0 ng/ml [411.01,050.0]) than in RRD (21.9 ng/ml [13.2127.0]) and in the controls (18.0 ng/ml [9.9199.0]) (p < 0.0001). Conclusion: The results indicate the possibility that tenascin-C is involved in the pathogenesis of PVR.Copyright © 2003 S. Karger AG, Basel
- Subjects
PROLIFERATIVE vitreoretinopathy; VITREOUS body diseases; RETINAL diseases; TENASCIN; EXTRACELLULAR matrix proteins; EYE
- Publication
Ophthalmologica, 2003, Vol 217, Issue 6, p422
- ISSN
0030-3755
- Publication type
Article
- DOI
10.1159/000073073