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- Title
Cardiac amyloidosis: diagnostic challenges and recent advancement in the treatment of transthyretin amyloidosis (ATTR).
- Authors
Rahman, Tanvir; Moghadam, Reihaneh C; Agarwal, Vikram V; Reiss, Craig K
- Abstract
ATTR-CA is an under-reported cause of congestive heart failure (CHF) and cardiac arrhythmias. Heightened clinical suspicion along with a multimodal investigative approach is often required in diagnosing this potentially fatal condition. Tafamidis and inotersen have shown promising results in terms of progression-free survival by ameliorating CHF symptoms and peripheral neuropathies in clinical trials. In this case series of five patients, we present three wild-type cardiac amyloidosis (ATTRwt-CA), one familial cardiac amyloidosis (ATTRm-CA) and one primary cardiac (AL-CA). The diagnostic modality was different for each patient. ATTRwt-CA, ATTRm-CA and AL-CA patients received tafamidis, inotersen and chemotherapy with bone marrow stem-cell transplantation, respectively.
- Subjects
CARDIAC amyloidosis; BONE marrow transplantation; AMYLOIDOSIS; ARRHYTHMIA; TRANSTHYRETIN; CONGESTIVE heart failure
- Publication
Oxford Medical Case Reports, 2021, Vol 2021, Issue 8, p1
- ISSN
2053-8855
- Publication type
Article
- DOI
10.1093/omcr/omab059