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- Title
Influence of C-H..π Hydrogen Bonds in Interleukins.
- Authors
Anand, Sudha; Anbarasu, Anand; Sethumadhavan, Rao
- Abstract
We have explored the roles played by C-H..π hydrogen bonds in interleukins. Main-chain to side-chain C-H..π interactions are the predominant type of interactions in interleukins. There was an average of 15 C-H..π interactions per protein and also there was an average of one significant C-H..π interaction for every 14 residues in the interleukins investigated. Significant contribution to C-H..π interactions was only from Asp, Gly, His, Lys, Phe, Pro, Ser, Thr, Trp and Tyr in interleukins. Trp contributed both donor and acceptor atoms in main-chain to side-chain, main-chain to side-chain 5 member aromatic ring and side-chain to side-chain C-H..π interactions. Short and medium-range C-H..π interactions are the predominant type of interactions in interleukins. More than 50% of C-H..π interacting residues had a conservation score of ⩾ 6. Significant percentage of C-H..π interacting residues had one or more stabilization centers; hence these residues may also contribute additional stability to structure of interleukins.
- Subjects
INTERLEUKINS; HYDROGEN bonding; PROTEIN microarrays; CELL communication; HUMAN growth hormone; SCIENTIFIC method
- Publication
In Silico Biology, 2008, Vol 8, Issue 3/4, p261
- ISSN
1386-6338
- Publication type
Article