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- Title
Synthesis and Antibacterial Activity Study of N-Substituted Acetamide Derivatives of 4-Hydroxy-2-oxo-2H-Chromene.
- Authors
Aziz-ur-Rehman; Rasool, S.; Abbasi, M. A.; Siddiqui, S. Z.; Riaz, A.; Tahir, A.; Asif, H. M. A.; Ahmad, I.
- Abstract
The heterocyclic coumarin derivatives are well known for their biological potential. The presented work demonstrates the evaluation of some N-substituted acetamoyl derivatives of 4-hydroxy-2-oxo-2H-chromene (4) against certain strains of gram bacteria. First, N-substituted-2-bromoacetamide, 3a-r, were synthesized by the reaction of aralkyl/aryl amines, 1a-r, with 2-bromoacetyl bromide (2) in an aqueous medium under definite pH control. In the second step, the resulted electrophiles, 3a-r, were made to react 4 in a polar aprotic solvent using a weak base as an activator to synthesize the final N-substituted-2-[(2-oxo-2H-chromen-4-yl)oxy]acetamide, 5a-r. The synthesis of compounds, 5a-r, was corroborated by TLC initially and spectral data of IR, 1H-NMR and EIMS finally. The MIC results of antibacterial activity rendered these molecules valuable inhibitors of all the bacterial strains taken into account.
- Subjects
ANTIBACTERIAL agents; ACETAMIDE
- Publication
Pakistan Journal of Chemistry, 2015, Vol 5, Issue 2, p49
- ISSN
2220-2625
- Publication type
Article
- DOI
10.15228/2015.v05.i02.p01201508012309