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- Title
Heartbreaking Decisions: The Dogma and Uncertainties of Antimicrobial Therapy in Infective Endocarditis.
- Authors
Adema, Jennifer L.; Ahiskali, Aileen; Fida, Madiha; Mediwala Hornback, Krutika; Stevens, Ryan W.; Rivera, Christina G.
- Abstract
Infective endocarditis (IE) is a rare but increasingly prevalent disease with high morbidity and mortality, requiring antimicrobials and at times surgical intervention. Through the decades of healthcare professionals' experience with managing IE, certain dogmas and uncertainties have arisen around its pharmacotherapy. The introduction of new antimicrobials and novel combinations are exciting developments but also further complicate IE treatment choices. In this review, we provide and evaluate the relevant evidence focused around contemporary debates in IE treatment pharmacotherapy, including beta-lactam choice in MSSA IE, combination therapies (aminoglycosides, ceftaroline), the use of oral antimicrobials, the role of rifamycins, and long-acting lipoglycopeptides.
- Subjects
INFECTIVE endocarditis; MEDICAL personnel; DOGMA; CEFTAROLINE; RIFAMYCINS
- Publication
Pathogens, 2023, Vol 12, Issue 5, p703
- ISSN
2076-0817
- Publication type
Article
- DOI
10.3390/pathogens12050703