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- Title
Microbiota-Gut-Brain Communication in the SARS-CoV-2 Infection.
- Authors
Manosso, Luana M.; Arent, Camila O.; Borba, Laura A.; Ceretta, Luciane B.; Quevedo, João; Réus, Gislaine Z.
- Abstract
The coronavirus disease of 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome 2 (SARS-CoV-2). In addition to pneumonia, individuals affected by the disease have neurological symptoms. Indeed, SARS-CoV-2 has a neuroinvasive capacity. It is known that the infection caused by SARS-CoV-2 leads to a cytokine storm. An exacerbated inflammatory state can lead to the blood–brain barrier (BBB) damage as well as to intestinal dysbiosis. These changes, in turn, are associated with microglial activation and reactivity of astrocytes that can promote the degeneration of neurons and be associated with the development of psychiatric disorders and neurodegenerative diseases. Studies also have been shown that SARS-CoV-2 alters the composition and functional activity of the gut microbiota. The microbiota-gut-brain axis provides a bidirectional homeostatic communication pathway. Thus, this review focuses on studies that show the relationship between inflammation and the gut microbiota–brain axis in SARS-CoV-2 infection.
- Subjects
COVID-19; SARS-CoV-2; BLOOD-brain barrier; INFLAMMATION; CYTOKINE release syndrome; MENTAL illness
- Publication
Cells (2073-4409), 2021, Vol 10, Issue 8, p1993
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells10081993