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- Title
Treatment de‐intensification for low‐risk biochemical recurrence after radical prostatectomy: rational or risky?
- Authors
Roberts, Matthew J.; Hruby, George; Kneebone, Andrew; Martin, Jarad M.; Williams, Scott G.; Frydenberg, Mark; Murphy, Declan G.; Namdarian, Ben; Yaxley, John W.; Hofman, Michael S.; Davis, Ian D.; Emmett, Louise
- Abstract
Biochemical recurrence after radical prostatectomy, indicated by detectable serum PSA, is common and often signifies residual or relapsed prostate cancer. Salvage radiation therapy (RT) is the standard treatment, but recent trials have explored treatment intensification, resulting in increased toxicity. De-intensification of post-prostatectomy RT is an attractive option, but suitable predictive factors are lacking. Prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/CT has shown superior sensitivity for detecting metastases, and negative PSMA PET scans may indicate a subset of patients who can safely avoid salvage RT. Clinicians are uncertain about the optimal management of low-risk biochemical recurrence and support the need for risk-adjusted trials to guide treatment decisions.
- Subjects
RADICAL prostatectomy; POSITRON emission tomography; PROSTATE-specific membrane antigen; RADIOTHERAPY; SALVAGE therapy
- Publication
BJU International, 2023, Vol 132, Issue 2, p146
- ISSN
1464-4096
- Publication type
Article
- DOI
10.1111/bju.16086