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- Title
Sex-Specific Quantitative Trait Loci Govern Susceptibility to Theiler's Murine Encephalomyelitis Virus-Induced Demyelination.
- Authors
Butterfield, Russell J.; Roper, Randall J.; Rhein, Dominic M.; Melvold, Roger W.; Haynes, Lia; Ma, Runlin Z.; Doerge, R.W.; Teuscher, Cory
- Abstract
Susceptibility to Theiler's murine encephalomyelitis virus-induced demyelination (TMEVD), a mouse model for multiple sclerosis (MS), is genetically controlled. Through a monse-human comparative mapping approach, identification of candidate susceptibility loci for MS based on the location of TMEVD susceptibility loci may be possible. Composite interval mapping (CIM) identified quantitative trait loci (QTL) controlling TMEVD severity in male and female backcross populations derived from susceptible DBA/2J and resistant BALBc/ByJ mice. We report QTL on chromosomes 1, 5, 15, and 16 affecting male mice. In addition, we identified two QTL in female mice located on chromosome 1. Our results support the existence of three linked sex-specific QTL on chromosome 1 with opposing effects on the severity of the clinical signs of TMEV-induced disease in male and female mice.
- Subjects
ENCEPHALOMYELITIS; DEMYELINATION; MULTIPLE sclerosis; MICE; GENETICS
- Publication
Genetics, 2003, Vol 163, Issue 3, p1041
- ISSN
0016-6731
- Publication type
Article
- DOI
10.1093/genetics/163.3.1041