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- Title
Case Report: Successful Treatment With Monoclonal Antibodies in One APDS Patient With Prolonged SARS-CoV-2 Infection Not Responsive to Previous Lines of Treatment.
- Authors
Rivalta, Beatrice; Amodio, Donato; Giancotta, Carmela; Santilli, Veronica; Pacillo, Lucia; Zangari, Paola; Cotugno, Nicola; Manno, Emma Concetta; Finocchi, Andrea; Bernardi, Stefania; Colagrossi, Luna; Gentile, Leonarda; Russo, Cristina; Perno, Carlo Federico; Rossi, Paolo; Cancrini, Caterina; Palma, Paolo
- Abstract
We described the case of a patient affected by activated PI3K-kinase delta syndrome (APDS) and a long-lasting and pauci-symptomatic SARS-CoV-2 infection, treated with multiple therapeutic agents including remdesivir and SARS-CoV-2-neutralizing monoclonal antibodies. We detected the clearance of the virus 105 days from the first positive swab and 7 days after monoclonal antibody administration. At genotyping, the SARS-CoV-2 virus resulted as wild type on all samples tested. This case shows the monoclonal antibodies' good tolerability and efficacy in reducing viral shedding in long-lasting infections refractory to other treatments.
- Subjects
MONOCLONAL antibodies; TREATMENT effectiveness; SARS-CoV-2; VIRAL shedding; INFECTION
- Publication
Frontiers in Immunology, 2022, Vol 13, p1
- ISSN
1664-3224
- Publication type
Correction Notice
- DOI
10.3389/fimmu.2022.891274