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- Title
False Negative Rate of Sentinel Lymph Node Biopsy in Multicentric and Multifocal Breast Cancers May be Higher in Cases with Large Additive Tumor Burden.
- Authors
Fearmonti, Regina M.; Batista, Larissa I.; Meric-Bernstam, Funda; Bedrosian, Isabelle; Kuerer, Henry M.; Hunt, Kelly K.; Singletary, S. Eva; Babiera, Gildy V.
- Abstract
We aimed to evaluate the feasibility of sentinel lymph node biopsy (SLNB) in multicentric/ multifocal breast cancer. In this prospective study, 23 women with multicentric/multifocal breast cancer underwent SLNB at our institution from April 2002 to February 2006. Presence of preoperative axillary metastases was confirmed by FNA. Patients underwent sub-areolar radiopharmaceutical injection ± isosulfan blue to perform SLNB, then completion ALND. The false-negative (FN) rate of SLNB was determined based upon final pathology. Twenty women with multicentric and three with multifocal invasive carcinoma were enrolled. The SLN identification rate was 100%. The overall FN rate of SLNB was 15% (95% CI 0.0466, 0.4281). Both cases with FN SLNB had multicentric disease, pathologic stage III breast cancer and a larger tumor burden compared with the study population. SLNB using sub-areolar injection is feasible for patients with multicentric/multifocal breast cancer yet may be associated with a higher FN rate in patients with large additive tumor burden.
- Subjects
LYMPH node diseases; BREAST cancer patients; LYMPHATIC metastasis; RADIOPHARMACEUTICALS; CANCER in women; TUMOR diagnosis; DIAGNOSIS
- Publication
Breast Journal, 2009, Vol 15, Issue 6, p645
- ISSN
1075-122X
- Publication type
Article
- DOI
10.1111/j.1524-4741.2009.00813.x