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- Title
Stability of E-cadherin methylation status in gastric mucosa associated with histology changes.
- Authors
CHAN, A. O. O.; HUANG, C.; HUI, W. M.; CHO, C. H.; YUEN, M. F.; LAM, S. K.; RASHID, A.; WONG, B. C.‐Y.
- Abstract
Background We have previously shown reversal of E-cadherin methylation in gastric mucosa from patients with dyspepsia at week 6 after Helicobacter pylori-eradication therapy. But the long-term methylation status of these patients was unknown. Aim To investigate the methylation status at E-cadherin at year 3 after H. pylori-eradication therapy. Methods 35 patients (25 with and 10 without H. pylori eradicated) enrolled in our previous study were recruited into the present study (year 3 analysis). Methylation at E-cadherin was evaluated by methylation-specific polymerase chain reaction method. Results There was no difference in age and sex distribution in the two groups. Methylation at E-cadherin in patients with H. pylori eradicated at weeks 0, 6 and year 3 were 52%, 20% and 20%, respectively. Concordant methylation status at week 6 and year 3 was 92%. Methylation at E-cadherin in patients without H. pylori at weeks 0, 6 and year 3 were 50%, 60% and 60%, respectively. Concordant methylation status between week 6 and year 3 was 90%. Stability of E-cadherin methylation status was associated with histological changes. No association between E-cadherin methylation status and age was observed. Conclusion The methylation pattern is stable for a long period, thus suggesting the effect of environment on methylation.
- Subjects
MEDICAL research; GASTRIC mucosa; CADHERINS; METHYLATION; INDIGESTION; HELICOBACTER pylori infections; THERAPEUTICS; GASTROINTESTINAL mucosa
- Publication
Alimentary Pharmacology & Therapeutics, 2006, Vol 24, Issue 5, p831
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2006.03032.x