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- Title
High seroprevalence of anti-SARS-CoV-2 antibodies in the capital of Chad.
- Authors
Deutou Wondeu, Andrillene Laure; Abdelrazakh, Fatima; Abakar, Mahamat Fayiz; Yandai, Fissou Henry; Nodjikouambaye, Aleyo Zita; Djimtoibaye, Djallaye; Kimala, Pidou; Nadjiadjim, Noel; Naïbeï, Nathan; Takoudjou Dzomo, Guy Rodrigue; Atturo, Sabrina; Linardos, Giulia; Russo, Cristina; Perno, Carlo Federico; Moussa, Ali Mahamat; Yokouide, Allarangar; Tchidjou, Hyppolite Kuekou; Colizzi, Vittorio; Choua, Ouchemi
- Abstract
Background. Since the start of the COVID-19 pandemic, Chad has had 7,417 confirmed cases and 193 deaths, one of the lowest in Africa. Objective. This study assessed SARS-CoV-2 immunity in N'Djamena. Methods. In August-October 2021, eleven N'Djamena hospitals collected outpatient data and samples. IgG antibodies against SARSCoV-2 nucleocapsid protein were identified using ELISA. "Bambino Gesù" Laboratory, Rome, Italy, performed external quality control with chemiluminescence assay. Results. 25-34-year-old (35.2%) made up the largest age group at 31.9±12.6 years. 56.4% were women, 1.3 women/men. The 7th district had 22.5% and the 1st 22.3%. Housewives and students dominated. Overall seroprevalence was 69.5% (95% CI: 67.7-71.3), females 68.2% (65.8-70.5) and males 71.2% (68.6-73.8). >44-year-old had 73.9% seroprevalence. Under-15s were 57.4% positive. Housewives (70.9%), civil servants (71.5%), and health workers (9.7%) had the highest antibody positivity. N'Djamena's 9th district had 73.1% optimism and the 3rd district had 52.5%. Seroprevalences were highest at Good Samaritan Hospital (75.4%) and National General Referral Hospital (74.7%). Conclusion. Our findings indicate a high circulation of SARSCoV-2 in N'Djamena, despite low mortality and morbidity after the first two COVID-19 pandemic waves. This high seroprevalence must be considered in Chad's vaccine policy.
- Subjects
CHAD; SEROPREVALENCE; COVID-19 pandemic; IMMUNOGLOBULINS; CHEMILUMINESCENCE assay; AGE groups
- Publication
Journal of Public Health in Africa, 2022, Vol 13, Issue 4, p1
- ISSN
2038-9922
- Publication type
Article
- DOI
10.4081/jphia.2022.2255