We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The cognitive and behavioural profile of Amyotrophic Lateral Sclerosis: Application of the consensus criteria.
- Authors
Consonni, Monica; Iannaccone, Sandro; Cerami, Chiara; Frasson, Paola; Lacerenza, Marco; Lunetta, Christian; Corbo, Massimo; Cappa, Stefano F.
- Abstract
OBJECTIVE: The study aims to assess the spectrum of cognitive and behavioural disorders in patients affected by Amyotrophic Lateral Sclerosis (ALS) according to the recent consensus criteria [9]. The study also intends to assess the impact of physical disability on cognitive and behavioural abnormalities. METHODS: Detailed neurological, neuropsychological and neurobehavioral evaluations were administered to 23 ALS patients, 11 Lower Motor Neuron Disease (LMND) patients and 39 healthy controls. Strong et al.'s criteria [9] were applied to diagnose the presence of cognitive/behavioural impairment. Clinical and neuropsychological scores were used for group comparisons and correlation analyses. RESULTS: In comparison with LMND and controls, a subgroup of ALS patients (∼⃒30%) manifested executive dysfunction, which was severe enough to classify them as cognitively impaired. Action naming difficulties and short-term memory deficits were also observed. Aspontaneity, disorganization and mental rigidity reached clinical relevance in 20% of ALS patients. A small percentage of ALS patients (13%) also had comorbid dementia. The cognitive or behavioural status was not related to the clinical features of ALS. CONCLUSION: The use of consensus criteria for cognitive and behavioural impairment and the comparison with the LMND group proved useful in defining the spectrum of non-motor manifestations of ALS.
- Subjects
AMYOTROPHIC lateral sclerosis; COGNITION disorders; BEHAVIOR disorders; NEUROBEHAVIORAL disorders; NEUROPSYCHOLOGICAL tests; MOTOR neuron diseases; MILD cognitive impairment; DIAGNOSIS
- Publication
Behavioural Neurology, 2013, Vol 27, Issue 2, p143
- ISSN
0953-4180
- Publication type
Article
- DOI
10.1155/2013/126010