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- Title
Symptoms Relevant to Surveillance for Ovarian Cancer.
- Authors
Ore, Robert M.; Baldwin, Lauren; Woolum, Dylan; Elliott, Erika; Wijers, Christiaan; Chieh-Yu Chen; Miller, Rachel W.; DeSimone, Christopher P.; Ueland, Frederick R.; van Nagell, John R.; Pavlik, Edward J.; Kryscio, Richard J.
- Abstract
To examine how frequently and confidently healthy women report symptoms during surveillance for ovarian cancer. A symptoms questionnaire was administered to 24,526 women over multiple visits accounting for 70,734 reports. A query of reported confidence was included as a confidence score (CS). Chi square, McNemars test, ANOVA and multivariate analyses were performed. 17,623 women completed the symptoms questionnaire more than one time and >9500 women completed it more than one four times for >43,000 serially completed questionnaires. Reporting ovarian cancer symptoms was ~245 higher than ovarian cancer incidence. The positive predictive value (0.073%) for identifying ovarian cancer based on symptoms alone would predict one malignancy for 1368 cases taken to surgery due to reported symptoms. Confidence on the first questionnaire (83.3%) decreased to 74% when more than five questionnaires were completed. Age-related decreases in confidence were significant (p < 0.0001). Women reporting at least one symptom expressed more confidence (41,984/52,379 = 80.2%) than women reporting no symptoms (11,882/18,355 = 64.7%), p < 0.0001. Confidence was unrelated to history of hormone replacement therapy or abnormal ultrasound findings (p = 0.30 and 0.89). The frequency of symptoms relevant to ovarian cancer was much higher than the occurrence of ovarian cancer. Approximately 80.1% of women expressed confidence in what they reported.
- Subjects
OVARIAN cancer diagnosis; SYMPTOMS; ETIOLOGY of ovarian cancer; OVARIAN cancer patients; OVARIAN cancer prevention; OVARIAN cancer treatment
- Publication
Diagnostics (2075-4418), 2017, Vol 7, Issue 1, p18
- ISSN
2075-4418
- Publication type
Article
- DOI
10.3390/diagnostics7010018