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- Title
NMR-Based Chromatography Readouts: Indispensable Tools to "Translate" Analytical Features into Molecular Structures.
- Authors
Seger, Christoph; Sturm, Sonja
- Abstract
Gaining structural information is a must to allow the unequivocal structural characterization of analytes from natural sources. In liquid state, NMR spectroscopy is almost the only possible alternative to HPLC-MS and hyphenating the effluent of an analyte separation device to the probe head of an NMR spectrometer has therefore been pursued for more than three decades. The purpose of this review article was to demonstrate that, while it is possible to use mass spectrometry and similar methods to differentiate, group, and often assign the differentiating variables to entities that can be recognized as single molecules, the structural characterization of these putative biomarkers usually requires the use of NMR spectroscopy.
- Subjects
MOLECULAR structure; CHROMATOGRAPHIC analysis; MASS spectrometry; NMR spectrometers; SINGLE molecules
- Publication
Cells (2073-4409), 2022, Vol 11, Issue 21, p3526
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells11213526