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- Title
Highly Selective Vapor and Liquid Phase Transfer Hydrogenation of Diaryl and Polycyclic Ketones with Secondary Alcohols in the Presence of Magnesium Oxide as Catalyst.
- Authors
Gliński, Marek; Markowska, Anna; Wrońska, Laura; Jerzak, Anna; Tarkowska, Magdalena; Parola, Valeria La
- Abstract
MgO has been shown to catalyze an almost quantitative hydrogen transfer from 2-octanol as the hydrogen donor to benzophenone to form benzhydrol, a useful intermediate product in the pharmaceutical industry. The hydrogen transfer from a series of alcohols to the carbonyl group of benzophenone, its ten derivatives, four polycyclic ketones, and 2-naphthyl phenyl ketone was carried out in liquid (LP) or vapor phase (VP). The dependence of reactivity on the structure of the hydrogen donor, reaction temperature, donor-acceptor ratio, amount of catalyst, and the type and position of substituents has been established. For both reaction modes, optimal conditions for selective synthesis of the alcohols were determined and side reactions were investigated. The results indicate that the reactivity of the ketone is suppressed by the presence of a methyl substituent in the ortho position to a much greater extent in LP mode. A scale-up was demonstrated in the liquid phase mode.
- Subjects
TRANSFER hydrogenation; MAGNESIUM oxide; KETONES; GASES; BENZOPHENONES; CARBONYL group; HYDROXYBENZOPHENONES
- Publication
Catalysts (2073-4344), 2021, Vol 11, Issue 5, p574
- ISSN
2073-4344
- Publication type
Article
- DOI
10.3390/catal11050574