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- Title
Inhibition of human vascular endothelial cells proliferation by terbinafine.
- Authors
Ho, Pei-Yin; Liang, Yu-Chih; Ho, Yuan-Soon; Chen, Chiung-Tong; Lee, Wen-Sen
- Abstract
We have demonstrated previously that terbinafine (TB), an oral antifungal agent used in the treatment of superficial mycosis, suppresses proliferation of various cultured human cancer cells in vitro and in vivo by inhibiting DNA synthesis and activating apoptosis. In our study, we further demonstrated that TB at a range of concentrations (0-120 μM) dose-dependently decreased cell number in cultured human umbilical vascular endothelial cells (HUVEC). Terbinafine was not cytotoxic at a concentration of 120 μM, indicating that it may have an inhibitory effect on the cell proliferation in HUVEC. The TB-induced inhibition of cell growth rate is reversible. [
- Publication
International Journal of Cancer, 2004, Vol 111, Issue 1, p51
- ISSN
0020-7136
- Publication type
Article
- DOI
10.1002/ijc.20039