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- Title
Coexistence of T-Large Granular Lymphocyte Leukemia and Peripheral T Cell Lymphoma-NOS with Indolent Behavior.
- Authors
Guarnera, Luca; Boldrini, Valentina; Pasqualone, Gianmario; Cimino, Carolina; Meddi, Elisa; Laureana, Roberta; Trivigno, Donata; Del Poeta, Giovanni; Mauriello, Alessandro; Anemona, Lucia; Postorino, Massimiliano; Cantonetti, Maria
- Abstract
T-cell lymphomas and leukemias are highly heterogeneous groups of rare disorders. We report a case of a 68-year-old man patient who developed two different T-cell neoplasms (Large Granular Lymphocyte Leukemia [LGLL] in 2018 and Peripheral T-cell non-Hodgkin lymphoma not otherwise specified [PTCL-NOS] in 2019) with a previous diagnosis of B-cell marginal zone lymphoma in 2010, treated with two lines of chemo-immunotherapy. The coexistence of these different T-cell neoplasms is rarely reported in the literature. Moreover, it is usually described as an LGLL transformation into PTCL-NOS; differently from these examples, herein, the simultaneous conditions appear to be driven by different T-cell clones. Furthermore, the PTCLNOS had quite unusual behavior, with good disease control without intensive treatment. Because of these features, it could belong to a subgroup of indolent PTCL-NOS, not yet described in the WHO classification of T-cell neoplasms, which could benefit from less aggressive treatment.
- Subjects
MUCOSA-associated lymphoid tissue lymphoma; T cells; LYMPHOCYTES; T-cell lymphoma; LEUKEMIA
- Publication
Mediterranean Journal of Hematology & Infectious Diseases, 2022, Vol 14, Issue 1, p1
- ISSN
2035-3006
- Publication type
Case Study
- DOI
10.4084/MJHID.2022.006