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- Title
Maternal pre-pregnancy BMI and offspring hyperactivity–inattention trajectories from 3 to 8 years in the EDEN birth cohort study.
- Authors
Dow, Courtney; Galera, Cédric; Charles, Marie-Aline; Heude, Barbara
- Abstract
Evidence suggests obesity during pregnancy is associated with offspring attention-deficit hyperactivity disorder. However, studies have been limited to evaluating the association at a single age with inadequate data on important maternal lifestyle confounders and unmeasured familial confounding. The objective of this study was to examine the association between maternal pre-pregnancy body mass index (BMI) and child hyperactivity–inattention symptoms (HIS) at 3, 5 and 8 years. Data came from the EDEN mother–child cohort. Maternal pre-pregnancy BMI status (kg/m2) was calculated using pre-pregnancy weight and height (self-reported by mothers or measured by midwives). HIS were assessed by parental-report on the Strengths and Difficulties Questionnaire at 3, 5 and 8 years of age and used to derive developmental trajectories of HIS (n = 1428). Multivariate models were adjusted for confounders including socioeconomic status, maternal lifestyle behaviours (exercise, diet, smoking, alcohol), childcare and a stimulating home environment. Paternal BMI was used as a negative control. Compared to a normal pre-pregnancy BMI, pre-pregnancy maternal obesity was positively associated with increased odds of a high HIS trajectory between 3 and 8 years old in both unadjusted and adjusted logistic regression (adjusted odds ratio [aOR] 1.87 [95% CI 1.12, 3.12]). Pre-pregnancy overweight was not significantly associated after adjustment for confounders (aOR 1.32 [0.87, 2.01]). Maternal pre-pregnancy obesity, but not overweight, was associated with increased likelihood of a high HIS trajectory in children from 3 to 8 years old. This association persisted despite controlling for many important maternal lifestyle factors and paternal BMI. Further research is warranted to identify possible mediators involved.
- Subjects
OBESITY complications; RISK factors of attention-deficit hyperactivity disorder; HYPERKINESIA; LIFESTYLES; CONFIDENCE intervals; MULTIVARIATE analysis; PREGNANT women; BEHAVIOR disorders in children; RISK assessment; COMPARATIVE studies; SOCIAL classes; RESEARCH funding; DESCRIPTIVE statistics; BODY mass index; OBESITY in women; LONGITUDINAL method
- Publication
European Child & Adolescent Psychiatry, 2023, Vol 32, Issue 10, p2057
- ISSN
1018-8827
- Publication type
Article
- DOI
10.1007/s00787-022-02047-x