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- Title
The Effects of Panax Ginseng on Lipid Profile, Pro-oxidant: Antioxidant Status and High-sensitivity C Reactive Protein Levels in Hyperlipidemic Patients in Iran.
- Authors
Delui, Mahdy Hassanzadeh; Fatehi, Hedayatollah; Manavifar, Morteza; Amini, Maral; Ghayour-Mobarhan, Majid; Zahedi, Mahdi; Ferns, Gordon
- Abstract
Background: Because of the conflicting results from previous studies regarding the efficacy of ginseng on lipid profile and anti inflammatory and anti proliferative activities of its components, we aimed to evaluate the effects of Panax ginseng on lipid profile, pro-oxidant - anti-oxidant status and high-sensitivity C reactive protein (hs-CRP) levels. Methods: Forty Iranian hyperlipidemic patients were randomly assigned to placebo (n = 20) or control (n = 20) groups in this double blind randomized controlled trial. The ginseng or placebo was taken two capsules twice a day for 8 weeks. Total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fasting blood glucose, serum creatinine and hs-CRP levels and pro-oxidant - anti-oxidant balance (PAB) were estimated before and after intervention. Results: There were no significant differences between the two groups with respect to changes in serum TG, LDL-C, HDL-C, and TC/HDL-C levels. Nor were there significant differences between the two groups with respect to changes in hs-CRP level and PAB from baseline to week 8. Conclusions: Our study demonstrates that ginseng does not have significant effects on lipid profile, Hs-CRP level and PAB. Further clinical studies, with a larger sample size, more prolonged period of therapy are needed to investigate the therapeutic effects of ginseng.
- Subjects
GINSENG; ANTIOXIDANTS; DRUG efficacy; ANTI-inflammatory agents; HYPERLIPIDEMIA; TRIGLYCERIDES; HIGH density lipoproteins
- Publication
International Journal of Preventive Medicine, 2013, Vol 4, Issue 9, p1045
- ISSN
2008-7802
- Publication type
Article