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- Title
New Value of Acorus tatarinowii / gramineus Leaves as a Dietary Source for Dementia Prevention.
- Authors
Umeda, Tomohiro; Sakai, Ayumi; Shigemori, Keiko; Nakata, Kunio; Nakajima, Ryota; Yamana, Kei; Tomiyama, Takami
- Abstract
The rhizomes of Acorus tatarinowii Schott and Acorus gramineus Solander are widely used for treating amnesia in traditional Chinese medicine. In contrast, their leaves are usually discarded without their medicinal properties being known. Here, we found that the hot water extract of leaves improved cognition and tau pathology in model mice of frontotemporal dementia, similar to or even better than that of rhizomes. To explore the optimal method of processing, we made three preparations from dried leaves: hot water extract, extraction residue, and non-extracted simple crush powder. Among them, the simple crush powder had the strongest effect on tauopathy in mice. The crush powder also ameliorated Aβ and α-synuclein pathologies and restored cognition in mouse models of Alzheimer's disease and dementia with Lewy bodies. These findings suggest the potential of Acorus tatarinowii/gramineus leaves as a dietary source for dementia prevention and reveal that simple crushing is a better way to maximize their efficacy.
- Subjects
DEMENTIA prevention; ALZHEIMER'S disease prevention; TAU proteins; LEWY body dementia; RESEARCH funding; MICE; ANIMAL experimentation; DEMENTIA; LEAVES; ANALYTICAL chemistry techniques; COGNITION
- Publication
Nutrients, 2024, Vol 16, Issue 11, p1589
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16111589