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- Title
Prevalence and Relevance of Vitamin D Deficiency in Newly Diagnosed Breast Cancer Patients: A Pilot Study.
- Authors
Zemlin, Cosima; Altmayer, Laura; Stuhlert, Caroline; Schleicher, Julia Theresa; Wörmann, Carolin; Lang, Marina; Scherer, Laura-Sophie; Thul, Ida Clara; Spenner, Lisanne Sophie; Simon, Jana Alisa; Wind, Alina; Kaiser, Elisabeth; Weber, Regine; Goedicke-Fritz, Sybelle; Wagenpfeil, Gudrun; Zemlin, Michael; Solomayer, Erich-Franz; Reichrath, Jörg; Müller, Carolin
- Abstract
(1) Background: Vitamin D plays an important role in many types of cancer. It was the aim of this study to analyze serum 25-hydroxyvitamin D (25(OH)D) levels in newly diagnosed breast cancer patients, and the association with prognostic and lifestyle factors. (2) Methods: 110 non-metastatic breast cancer patients were included in the prospective observational "BEGYN" study at Saarland University Medical Center between September 2019 and January 2021. At the initiation visit, serum 25(OH)D levels were measured. Clinicopathological data on prognosis, nutrition, and lifestyle were extracted from data files and obtained using a questionnaire. (3) Results: Median serum 25(OH)D in breast cancer patients was 24 ng/mL (range 5–65 ng/mL), with 64.8% of patients being vitamin D deficient. 25(OH)D was higher among patients that reported the use of vitamin D supplements (43 ng/mL versus 22 ng/mL; p < 0.001), and in summer compared to other seasons (p = 0.03). Patients with moderate vitamin D deficiency were less likely to have triple negative breast cancer (p = 0.047). (4) Conclusions: Routinely measured vitamin D deficiency is common in breast cancer patients and needs to be detected and treated. However, our results do not support the hypothesis that vitamin D deficiency may be a main prognostic factor for breast cancer.
- Subjects
BLOOD serum analysis; BREAST cancer prognosis; BREAST tumor diagnosis; THERAPEUTIC use of vitamin D; PILOT projects; LIFESTYLES; ACADEMIC medical centers; SCIENTIFIC observation; CANCER patients; VITAMIN D; DIETARY supplements; TREATMENT effectiveness; COMPARATIVE studies; DISEASE prevalence; QUESTIONNAIRES; DESCRIPTIVE statistics; RESEARCH funding; VITAMIN D deficiency; NEEDS assessment; BREAST tumors; LONGITUDINAL method; DISEASE complications
- Publication
Nutrients, 2023, Vol 15, Issue 6, p1450
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15061450