We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Metabolic Effects and Safety Aspects of Acute D-allulose and Erythritol Administration in Healthy Subjects.
- Authors
Teysseire, Fabienne; Bordier, Valentine; Budzinska, Aleksandra; Van Oudenhove, Lukas; Weltens, Nathalie; Beglinger, Christoph; Wölnerhanssen, Bettina K.; Meyer-Gerspach, Anne Christin
- Abstract
The rapid increase in sugar consumption is associated with various negative metabolic and inflammatory effects; therefore, alternative sweeteners become of interest. The aim of this study was to investigate the metabolic effects and safety aspects of acute D-allulose and erythritol on glucose, insulin, ghrelin, blood lipids, uric acid, and high-sensitive C-reactive protein (hsCRP). In three study visits, 18 healthy subjects received an intragastric administration of 25 g D-allulose or 50 g erythritol, or 300 mL tap water (placebo) in a randomized, double-blind and crossover order. To measure the aforementioned parameters, blood samples were drawn at fixed time intervals. Glucose and insulin concentrations were lower after D-allulose compared to tap water (p = 0.001, dz = 0.91 and p = 0.005, dz = 0.58, respectively); however, Bayesian models show no difference for insulin in response to D-allulose compared to tap water, and there was no effect after erythritol. An exploratory analysis showed that ghrelin concentrations were reduced after erythritol compared to tap water (p = 0.026, dz = 0.59), with no effect after D-allulose; in addition, both sweeteners had no effect on blood lipids, uric acid and hsCRP. This combination of properties identifies both sweeteners as excellent candidates for effective and safe sugar alternatives.
- Subjects
C-reactive protein; RESEARCH; STATISTICS; ANALYSIS of variance; MONOSACCHARIDES; BLOOD sugar; INSULIN; GHRELIN; RANDOMIZED controlled trials; DESCRIPTIVE statistics; BLIND experiment; URIC acid; DATA analysis software; CROSSOVER trials; BODY mass index; DATA analysis; SUGAR alcohols; PATIENT safety; LIPIDS
- Publication
Nutrients, 2023, Vol 15, Issue 2, p458
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15020458