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- Title
Periconceptional Maternal Diet Characterized by High Glycemic Loading Is Associated with Offspring Behavior in NEST.
- Authors
Alick, Candice L.; Maguire, Rachel L.; Murphy, Susan K.; Fuemmeler, Bernard F.; Hoyo, Cathrine; House, John S.
- Abstract
Maternal periconceptional diets have known associations with proper offspring neurodevelopment. Mechanisms for such associations include improper energy/nutrient balances between mother and fetus, as well as altered offspring epigenetics during development due to maternal nutrient and inflammatory status. Using a comprehensive food frequency questionnaire and assessing offspring temperament with the Infant-Toddler Social and Emotional Assessment (n = 325, mean age = 13.9 months), we sought to test whether a maternal periconceptional diet characterized by high glycemic loading (MGL) would affect offspring temperament using adjusted ordinal regression. After limiting false discovery to 10%, offspring born to mothers in tertile 3 of glycemic loading (referent = tertile 1) were more likely to be in the next tertile of anxiety [OR (95% CI) = 4.51 (1.88–11.07)] and inhibition-related behaviors [OR (95% CI) = 3.42 (1.49–7.96)]. Male offspring were more likely to exhibit impulsive [OR (95% CI) = 5.55 (1.76–18.33)], anxiety [OR (95% CI) = 4.41 (1.33–15.30)], sleep dysregulation [OR (95% CI) = 4.14 (1.34–13.16)], empathy [6.68 (1.95–24.40)], and maladaptive behaviors [OR (95% CI) = 9.86 (2.81–37.18)], while females were more likely to exhibit increased anxiety-related behaviors [OR (95% CI) = 15.02 (3.14–84.27)]. These associations persisted when concurrently modeled with the maternal–Mediterranean dietary pattern. In a subset (n = 142), we also found MGL associated with increased mean methylation of the imprint control region of SGCE/PEG10. In conclusion, these findings highlight the importance of maternal dietary patterns on offspring neurodevelopment, offering avenues for prevention options for mothers.
- Subjects
MOTHERS; MEDITERRANEAN diet; FOOD habits; EMPATHY; CONFIDENCE intervals; IMPULSIVE personality; NUTRITIONAL requirements; DIET; CARBOHYDRATE content of food; REGRESSION analysis; GLYCEMIC index; RISK assessment; SLEEP disorders; CHILD psychopathology; QUESTIONNAIRES; TEMPERAMENT; DESCRIPTIVE statistics; INFANT psychology; ANXIETY; ODDS ratio; PRECONCEPTION care; PSYCHOLOGICAL stress
- Publication
Nutrients, 2021, Vol 13, Issue 9, p3180
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13093180