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- Title
Transient photocurrents in a subthreshold evidence accumulator accelerate perceptual decisions.
- Authors
Wong, Timothy L. H.; Talbot, Clifford B.; Miesenböck, Gero
- Abstract
Perceptual decisions are complete when a continuously updated score of sensory evidence reaches a threshold. In Drosophila, αβ core Kenyon cells (αβc KCs) of the mushroom bodies integrate odor-evoked synaptic inputs to spike threshold at rates that parallel the speed of olfactory choices. Here we perform a causal test of the idea that the biophysical process of synaptic integration underlies the psychophysical process of bounded evidence accumulation in this system. Injections of single brief, EPSP-like depolarizations into the dendrites of αβc KCs during odor discrimination, using closed-loop control of a targeted opsin, accelerate decision times at a marginal cost of accuracy. Model comparisons favor a mechanism of temporal integration over extrema detection and suggest that the optogenetically evoked quanta are added to a growing total of sensory evidence, effectively lowering the decision bound. The subthreshold voltage dynamics of αβc KCs thus form an accumulator memory for sequential samples of information. The rate at which third-order olfactory neurons integrate synaptic inputs to spike threshold is thought to determine the speed of odor discrimination in Drosophila. Here, authors compare the impact of subthreshold optogenetic membrane potential manipulations on decision-making.
- Subjects
OLFACTORY receptors; PHOTOCURRENTS; TEMPORAL integration; MEMBRANE potential; DIRECT costing; DROSOPHILA; DENDRITES
- Publication
Nature Communications, 2023, Vol 14, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-023-38487-5