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- Title
Non-Hodgkin's lymphoma after treatment of Hodgkin's disease: association with Epstein-Barr virus.
- Authors
List, Alan F.; Greer, John P.; Cousar, John B.; Stein, Richard S.; Flexner, John M.; Sinangil, Faruk; Davis, Jack; Volsky, David J.; Purtilo, David T.; List, A F; Greer, J P; Cousar, J B; Stein, R S; Flexner, J M; Sinangil, F; Davis, J; Volsky, D J; Purtilo, D T
- Abstract
Non-Hodgkin's lymphoma occurs infrequently as a late complication of obscure cause after treatment of Hodgkin's disease. We investigated the possible role of Epstein-Barr virus in the pathogenesis of such secondary malignancies of B-cell lineage. Two patients, aged 25 and 43 years, developed high-grade non-Hodgkin's lymphomas 12 and 8 years after radiation therapy for Hodgkin's disease. Serologic profiles in these patients showed evidence of acute and past Epstein-Barr virus infections, respectively. Molecular hybridization analysis showed the presence of multiple cellular equivalents of virus genome in tumor specimens from each patient. Our findings suggest that Epstein-Barr virus may play an integral role in the pathogenesis of non-Hodgkin's lymphoma of B-cell lineage that develops after treatment of Hodgkin's disease.
- Subjects
EPSTEIN-Barr virus; LYMPHOMAS; RADIOTHERAPY; HODGKIN'S disease; IMMUNOGLOBULIN genes; LYMPHOCYTE classification; COMPARATIVE studies; GENES; RESEARCH methodology; MEDICAL cooperation; MULTIPLE tumors; RESEARCH; TUMORS; VIRAL antibodies; EVALUATION research; LEUKOCYTE count; DISEASE complications
- Publication
Annals of Internal Medicine, 1986, Vol 105, Issue 5, p668
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-105-5-668